Found in the blood, high levels of homocysteine are linked directly to increased incidence of cardiovascular disease, including heart attacks and strokes and this link is particularly high in men. We appear to produce more of this compound as we age.
Studies on males of various ages reveal a strong correlation between high plasma homocysteine levels, heart disease and mortality.
So what does this have to do with creatine and heart disease? Keep reading.
Research on homocysteine levels and its production is a major focus of cardiovascular research. Some studies indicate that creatine synthesis within the body is a pathway that up-regulates homocysteine production. Conversely, we know that supplementation with creatine temporarily suppresses normal creatine synthesis within the body. The suppression of creatine synthesis in the body via supplementation is a clear biochemical pathway that down regulates the production of homocysteine.
Therefore, creatine supplementation is now being considered as a strategy for down-regulating homocysteine levels to decrease the risk of heart disease. This research is clear evidence creatine may protect against heart disease. And you thought creatine was only for big muscles!
Source: Am J Clin Nutr
