The body does have a feedback mechanism regarding the production of most energy substrates, including creatine. The research that has examined this topic has shown that creatine synthesis (produced in the liver), decreases in response to high blood creatine concentrations. This response is natural and reverses quickly once blood creatine concentrations decline.
Due to its ability to suppress creatine synthesis, creatine supplementation is now being considered by medical science as a strategy that may prevent heart disease, particularly in males. A medical paper written by Dr. M.F. McCarty, provided a sound theoretical basis to suggest that daily creatine supplementation would suppress normal creatine synthesis and thereby inhibit production of a compound called homocysteine. High levels of homocysteine in the blood are suspected to play a major part in the onset of heart disease. Therefore, your Micronized Creatine supplement may provide other important health benefits aside from helping you build muscle.
Source: Med Hypotheses 56 :5-7,2001
